3-(3{40 ,4{40 -Dichloro-6{40 -alkyl-phenyl)-delta, 2-pyrazoline derivatives

ABSTRACT

Novel pyrazolines are obtained by condensation of substituted propiophenones or vinyl-phenyl-ketones with substituted phenyl hydrazines. The products are useful as optical brighteners of a great variety of the shade of their fluorescence and of an improved fastness to light.

States Patent 1 [111 3,865,816 Mengler 1 Feb. 11, 1975 I5 3-(3,4'-I)ICIILORO-6-ALKYL-PHENYL)- 260/239.8

DELTA, Z-PYRAZOLINE DERIVATIVES [75] Inventor: IIeImut Mengler, Frankfurt/Main, [56] References Cited UNITED STATES PATENTS [73} Assignee: Farbwerke Hoechst 3.135.742 6/I964 Wagner etal. 260/239.9 Aktiengeseuschafl vormals Meiser 3.357988 I2/l967 Huusermann et ul 260/3I0 Lucius & g Frankfurt/Main 3.6292 l2/l97l KI'ZIUSC Cl lll.... 260/239.9 Germany FOREIGN PATENTS OR APPLICATIONS [22] Filed: Sept. 7, I972 l.900,349 8/1970 Germany 260/239.9 [21] Appl. No: 287,075 OTHER PUBLICATIONS V Stensby, Soap & Chemical Specialties, April 1967, pp. [30] Foreign Application Priority Data 414 Sept 9, 1971 Germany 2l450l9 I I Prmmry Exammer-Henry R. JlIes 521 US. Cl 260/239.9, 117/335 R, 260/239.7, Aswan Emmmeric' lalsle 2 0 239 2 0/2471 26O/2472 R Attorney, Agent, or F1rmCurt|s, MOITIS 8L Safford 260/247.2 A, 260/247.2 B, 260/247.5, 260/268 S, 260/283 R, 260/293.7, 260/296 [57] ABSTRACT 7 260/297 Rim/310 2606323 Novel pyrazolines are obtained by condensation of 26O/397'6 26O/397'7 260/455 substituted propiophenones or vinyl-phenyl-ketones 260/465 260/465 260/471 with substituted phenyl hydrazines. The products are 260/476 260511 260/515 260/518 useful as optical brighteners of a great variety of the 260/518 260/5081 ggo sg ggfsg z shade of their fluorescence and of an improved fastsst 1' ht. 511 Int. Cl C07d 49/00 M 0 {58] Field of Search zoo/239.9, 310 D, 239.7, 8 Claims, N0 ra ings 3-(3' .4DICHLORO-6'-ALKYL-PHENYL)-DELTA. Z-PYRAZOLHNE DERIVATIVES The present invention relates to 3-[3,4-dichloro-6- alkyl-phenyll-AZ-pyrazoline derivatives, a process for their manufacture and their use as optical brighteners.

Our copending patent application Ser. No. l22,528 now abandoned relates to compounds of the general formula I in which R has the meaning given above, V represents a hydrogen atom, a low-molecular alkyl group which may be substituted, a carboxy group, a carboxy group having a modified function, an aryl radical which may be substituted, or the radical of a heterocyclic ring system which may be substituted, and U, U and U which may be the same or different, represent, irrespective of each other, hydrogen or halogen atoms, carboxy groups or carboxy groups having modified functions, sulfo groups or sulfo groups having modified functions, unsubstituted lower alkylsulfonyl groups, cycloalkylsulfonyl groups having 4 8 carbon atoms, aralkylsulfonyl groups which may be substituted, preferably in the aryl radical, arylsulfonyl groups which may be substituted, lower alkyl groups or lower halogenoalkyl groups, are distinguished, compared to the pyrazoline brighteners hitherto known, by an improved color shade and fastness to light.

The term low-molecular" or lower" in connection with an aliphatic group is intended to cover such residues of up to 6, especially up to 4 carbon atoms, e.g. alkyl or alkoxy of l to 4 and alkenyl of 2 to 4 carbon atoms.

A carboxy group having modified functions means in the first instance the salts having colorless cations, the alkali metal or ammonium ions being preferred, and furthermore it means such functional derivatives of a carboxy group the carbon atom of which has 3 bonds to hetero atoms, particularly oxygen, sulfur, and nitrogen atoms, particularly the cyano group, a carboxylic acid ester group, a (thio)carboxylic acid thioester group of a carboxylic acid amide or hydrazide group. Suitable carboxylic acid ester groups correspond particularly to the general formula COOR in which R represents an alkyl group having up to 18 carbon atoms, which may be branched, a medium cycloalkyl radical having 4 to 8 carbon atoms, an aralkyl radical, particularly the benzyl and phenethyl radical, or an aryl radical, particularly a phenyl radical which may be substituted, in which case these radicals may contain further substituents, preferably a [lower dialkylamino, trialkylammonium, alkoxy or phemoxy group or a hetcrocyclic radical, particularly a saturated -membered heterocyclic such as the piperidyl and morpholyl radical and, if desired, the quaternary salts thereof. A suitable thiocarboxylic acid ester group is particularly one of the formula COS-R in which R represents a lower alkyl radical which may be substituted or an aryl radical which may be substituted, particularly a phenyl radical which may be substituted. A suitable carbocylic acid amide group is particularly one of the formula CONRR in which the radicals R and R irrespective of each other, represent hydrogen atoms or have the meaning of R or may form, also jointly with the nitrogen atom a heterocyclic ring which may contain further heteroatoms and which may be substituted, particularly a saturated 6-membered heterocyclic such as the piperidyl and morpholyl radical and, if desired, the quaternary salts thereof.

In analogy to the statements made hereinbefore a sulfo group having a modified function means the salts having colorless cations, preferably alkali metal or ammonium ions, and, furthermore, the derivatives in which the S0 group is bound to a hetero atom such as in the sulfonic acid ester group and in the sulfonamide group. As sulfonic acid ester group there is particularly mentioned one of the formula SO' OR in which R has the meaning given above, and a suitable sulfonic acid amide group is one of the formula SO NRR in which R and R have the meanings given above.

It is a prerequisite for the substituents which may exist at the radicals V, U, U and U that they do not impart a color to the molecule, do not affect the fluorescence and do not possess a disturbing fluorescence on their part. As far as cationactiwe or anionactive substituents are concerned, the same prerequisites are valid for the ion of opposite charge.

Of particular interest are compounds of the general formula ("1.)

in which R represents a lower alkyl group, W represents an alkyl group which may be substituted by a halogen atom or a hydroxy group, a carboxy group which may have a modified function, a phenyl group which may be substituted by halogen atoms, lower alkyl, lower alkoxy or sulfo groups, preferably a hydrogen atom, a sulfophenyl or disulfophenyl group, and U represents a hydrogen or halogen atom, especially a chlorine atom. a lower alkyl or haloalkyl g roup,'a lower alkyl sulfonyl group substituted by a phenyl group, a medium cycloalkylsulfonyl or a phenylsulfonyl group, preferably a carboxy group, a carboxy group of a modified function, a sulfonic acid group which may have a modified function or a lower alkylsulfonyl radical, and in which the radical U stands preferably in p-position.

The compoundsfll) of the present invention can be prepared, for example, by condensing in known manner ketones of the general formula (IV) or (V) a N-NH 2 I) in which U, U and U have the meanings given above, and if desired, converting in the pyrazolines thus obtained any existing sulfo or carboxy groups, either directly or, preferably, via their acid halides to carboxylic acid and sulfonic acid derivatives having a modified function.

The ketone of the general formula (IV) in which V represents a hydrogen atom and Z represents a chlorine atom are obtained in a Friedel-Crafts reaction from l-alkyl-3,4-dichlorobenzene and B-chloropropionyl chloride. The ketones of the general formula (V) are obtained by condensation of an appropriate aldehyde with 3,4-dichloro-fi-alkyl-acetophenone.

Examples of ketones of the general formula (IV) are: 3.3 ,4'-trichloro-6'-methyl-propiophenone, 3 ,4- dichloro-6'-methyl-3-dimethylamino-propiophenone hydrochloride, 3,3',4-trichloro-6-methylbutyrophenone, 3,3',4'-trichloro-6'- ethylpropiophenone, 3,3',4-trichloro-6'-methyl-3-carboxy-propiophenone and 3,3,4'-trichloro-6'-methyl-3- carbomethoxy-propiophenone.

Examples of the ketones of the general formula (V) are: (3,4-dichloro-o-methyl-phenyl )-vinyl-ketone,( 3,4-

dichloro-6-methyl-phenyl)-( 3,3-dimethyl-butenyl-l 4 ketone, (3,4-dichloro-6-methyl-phenyl )-(3,3-dimethyl- 4-chloro-butenyl-l)-ketone, (3,4-dichloro-6-methyl phen'yl)-( 3,3-dimethyl-4-hydroxy-butenyl-l )-ketone, (3,4-dichloro--methyl-phenyl)-styryl-ketone, (3,4- dichloro-6-methyl-phenyl)-(2-chloro-styryl)-ketone, (3,4-dichloro-6 methyl-phenyl)-(4-ehIoro-styryl)- ketone, (3,4-dichloro-6-methyl-phenyl)-(4-methoxy styryI)-ketone, (3,4-dichloro-6-methyl-phenyl)-(2- or 3-sulfo-styryl)-ketone and their alkali salts, particularly sodium salts, (3,4-dichloro-6-methylphenyl)-(2,4- disulfo-styryl)-ketone and its alkali metal salts, particularly disodium salt, (3,4-dichloro-o-methyl-phenyl)-(B- 2-thenyl-vinyl)-ketone, (3,4-dichloro-6-methylphenyl B-Z-furyl-vinyl )-ketone, (3 ,4-dichloro-6- methyl-phenyl)-(B-2-pyridyl-vinyl)-ketone as well as the corresponding ketones having a lower alkyl group with 2-4 carbon atoms in 6-position of the phenyl group, particularly an ethyl group.

Examples of phenylhydrazines of the general formula VI which may be used, if desired, in the form of their hydrochlorides or sulfates for the preparation of the compounds of the present invention corresponding to the general formula ll are:

phenylhydrazine, phenylhydrazine-3-carboxylic acid, phenyl hydrazine-4-carboxylic acid,4-carbomethoxyphenylhydrazine, 4-cyanophenylhydrazine, phenylhydrazine-2-sulfonic acid, phenylhydrazine-3- sulfonic acid, phenylhydrazine-4-sulfonic acid, phenylhydrazine-4-sulfonamide, phenylhydrazine-2,5- disulfonic acid, phenylhydrazine-4-methylsulfone, phenylhydrazine-4-ethylsulfone, Z-methylphenylhydrazine, 4-methyl-phenylhydrazine, 2-ethylphenylhydrazine, 2-chlord-phenylhydrazine, 3-chlorophenylhydrazine, 4-chloro-phenylhydrazine, 2,5-dichlormphenylhydrazine, 3,4-dichlorophenylhydrazine,2,4,6-trichloro-phenylhydrazine, 3 ,5- dichloro-phenyl-hydrazine, 3-fluoro-phenyl-hydrazine, 3,5-difluoro-phenylhydrazine, 4 -bromophenylhydrazine, 3-trifluoro-methyl-phenylhydrazine,

3,5-bis-(trifluoromethyl)-phenylhydrazine, 4-chloro-3- trifluoromethyl-phenylhydrazine,, 3-chlorophenylhydrazine-4-carboxylic acid, 3-chloro-4- carbomethoxyphenylhydrazine, Z -methylphenylhy drazine-4-sulfonic acid 4-methylphenylhydrazine-Z-sulfonic acid, Z-methylphenylhydrazine-4,5-disulfonic acid, 2-chlorophenylhydrazine 4-sulfonic acid, 2-chlorophenylhydrazine-S-sulfonic acid, 2,5-dichloro-phenylhydrazine-4-sulfonic acid, 2,3,6-trichlor'ophenylhydrazine-S-sulfonic acid, 2-chlor0-6-methylphenylhydrazine-4-sulfonic acid and 2-bromo-6- methyl-phenylhydrazine-4-sulfonic acid.

The condensation of the phenylhydrazines (V1) with the ketones of the formula (IV) or (V) is carried out according to known methods by boiling under reflux for several hours in lower alcohols or in a mixture of a polar solvent with water, if desired with the addition of mineral acids in catalytic amounts up to about 3 equivalents. When using ketones of the formula (IV) in which Z represents a lower dialkylamino group, the condensation may also be carriedout in the presence of alkaline condensing agents such as sodium carbonate or tertiary bases such as pyridine or a mixture of pyridine bases.

The pyrazoline-sulfonic acids and pyrazolinecarboxylic acids obtained in the manner described above with the use of sulfoor carboxy-substituted phenylhydrazines can be reacted according to known methods if desired via the respective acid halide, with amines or alcohols with formation of the respective amides or esters. The amines or alcohols in question may have further substituents on their part; as far as amino groups are concerned these may be quaternized according to known methods.

As amines there are mentioned primary and secondary aliphatic amines each having up to about carbon atoms in the aliphatic radicals, cycloaliphatic amines having preferably 4 to 8 carbon atoms in the cyclic radicals, araliphatic amines having preferably lower aliphatic bridge members and, if desired, aromatic amines preferably derived from mononuclear or binuclear aromates, particularly from a benzene which may be substituted, and heterocyclic amines, preferably mononuclear 5- or 6-membered, saturated or unsaturated heterocyclic amines which in addition may also have amino groups and preferably dialkylamino groups. There are mentioned, for example: methylamine, ethylamine, n-propylamine, B-amino-propionic acid nitrile, n-butylamine, stearylamine, allylamine, oleylamine, ethanolamine, cyclohexylamine, tetrahydroquinoline, benzylamine, dimethylamine, diethylamine, di-n-butylamine, diethanolamine, aniline, N- methyl-aniline, taurine, N-methyltaurine, glycine, N- methylglycine, B-dimethylamino-ethylamine, B-diethylamino-ethylamine, y-diethylamino-propylamine, N-methylbenzylamine, pyrrolidine, piperidine, N-(yamino-propyl )-piperidine, morpholine, N-(,Baminoethyl-morpholine), N-(y-amino-propyl morpholine,ethylene diamine, piperazine, N-(B- hydroxyethyl)-piperazine, N-(B-aminoethyhpiperazine, N-methyl-piperazine, N-ethoxycarbonylpiperazine, N-phenylpiperazine, and Z-aminopyridine.

As alcohols there are mentioned primary and secondary aliphatic alcohols having up to 18 carbon atoms in the aliphatic radicals, cycloaliphatic alcohols having 4 to 8 carbon atoms, and araliphatic alcohols preferably having lower aliphatic bridge members and preferably, as aryl radical, a benzene radical which may be substituted, which alcohols may carry further substituents such as hydroxy groups, lower alkoxy groups, preferably, however, lower dialkylamino and trialkylammonium groups, as well as saturated nitrogencontaining heterocyclic rings and their quaternization products, such as, for example:

methanol, ethanol, n-propanol, iso-propanol, nbutanol, isobutanol, tert, butanol, n-amylalcohol, isoamylalcohol, n-hexanol, n-octanol, dodecylalcohol, stearylalcohol, allylalcohol, oleylalcohol, butandiol(l,3), glycolmonoethyl ether, glycolmonomethyl ether, diglycolmonoethyl ether, 2-dimethylamino ethanol, Z-diethylamino ethanol, 2-(di-n-butylamino) ethanol, l -dimethylam ino-propanol-( 3 ldimethylaminopropanol-( 2 benzylalcohol, B-phenylethanol, Bphenoxyethanol, N-(B-hydroxyethyl)-pyrrolidine, N-(B-hydroxyethyl)-piperidine, N- (B-hydroxyethyl)-morpholine, N-(B-hydroxyethyl)-N- methylpiperazine, cyclohexanol; furthermore the phenols which may carry substitutents, such as phenol, the

mentioned ethyl mercaptan, isoa'myl mercaptan, me-- thoxymethyl mercaptan, benzyl mercaptan, thioglycolic acid, thioglycolic acid methyl ester, thioglycolic acid ethyl ester, thiophenol, 2-chlorothiophenol, 3- chlorothiophenol, 4-chlorothiophenol or thio-p-cresol.

The compounds of the present invention show in the form of solutions a more or less intense fluorescence of reddish blue to greenish blue color and are suitable for the optical brightening of various organic materials. Since the radicals V, U, U and ill in the compounds obtainable according to the invention can be varied within wide limits, the shade of the brightenings obtained and the affinity of these optical brighteners may be adapted to a large variety of substrates under the most different application conditions.

The water-insoluble compounds of the invention show good results, for example in the brightening of lacquers or synthetic fibers, for example, those made from acetyl cellulose, polyamides, polyurethanes, polyacrylonitrile, as well as of films, foils, strips or shaped articles made from these materials. The water-insoluble compounds may be employed in the form of solutions in organic solvents or in aqueous dispersions, preferably with the aid of a dispersing agent. As dispersing agents there may, for example, be used soaps, polyglycol ethers of fat alcohols, fatty amines or alkyl-phenols, cellulose sulphite waste liquors or condensation products of optionally alkylated naphthalene-sulphonic acids with formaldehyde, as well as polyvinyl alcohols which may also be partially acetylated.

The anionic water-soluble compounds are especially suitable for the optical brightening of acetyl cellulose, wool and, especially, synthetic polyamide fibres. When used in these materials they show an excellent degree of whiteness, preferably at a pH ranging between about 3 and about 6.

The cationic water-soluble compounds are especially suitable for the optical brightening of fibrous materials that can be dyed with basic dyestuffs, for example polyacrylonitrile fibres. An optimum degree of whiteness is obtained in an acid range at a pH of from 3 to 6.

The compounds of the invention may, moreover, also be incorporated in high-molecular-weight organic materials prior to or during the moulding operation. For example, they can be incorporated into moulding materials to be processed into films, foils, strips or shaped articles or they can be dissolved in the spinning solution prior to spinning into filaments. Suitable compounds may also be added to low-molecular-weight starting materials prior to polycondensation, as in the case of polyamide-6,6, or prior to polymerization.

The compounds of the present invention which contain sulfonamide groups are excellently suitable for the optical brightening of spun polyacrylonitrile fibers according to the dry spinning process. Compared to the known A -pyrazoline derivatives hitherto recommended for this purpose, the compounds of the present invention are distinguished by a very high degree of brilliant whiteness, a very good fastness to light, a good solubility in dimethylformamide, and particularly by their high stability during the acid after-treatment of the spinning material with oxalic acid. In this case the aforementioned optical brighteners, compared to the commercial pyrazoline brighteners for spinning material, are decomposed at a substantially less percentage.

When applied to fiber materials such as fleeces, knitted and woven fabrics, preferably made from synthetic polyamide fibers, acetyl cellulose or copolymers having a content of at least 85% of acrylonitrile, the compounds of the invention show a particularly high degree of whiteness when the fiber material is impregnated with solutions or dispersions of these compounds, and then squeezed in usual manner between rollers to a moisture content of about to 150% of its dry weight. The compounds of the formula (11) are preferably applied to the fiber in a concentration of from about 0.01 to 1%, calculated on the weight of the goods. In the case of synthetic polyamide fibers and acetate fibers, these are advantageously subsequently dried or thermosoled at temperatures of from about 100 to 220C, preferably about 150 to 200C. 1n the case of polyacrylonitrile, the material is advantageously dried, after padding, at temperatures of from about 120 to 150C and thermosoled. The treating time depends upon the temperature applied and is generally between about 20 and 300 seconds. According to this process, an especially high degree of whiteness is obtained by adding to the padding baths mixtures of adjuvants corresponding to Belgian Pat. No. 729 261.

Compared to compounds that carry in 3-position of the pyrazoline nucleus an unsubstituted phenyl radical or a phenyl radical substituted in para position by a halogen atom or an alkoxy, acy1amino,alkylamino or dialkylamino group, the compounds of the invention are distinguished by a substantially improved fastness to light according to DlN 54004 (German Industrial Standards), especially with a simultaneous wetting or weathering according to SNV (Swiss Standards Association) 95808.

The compounds of the formula (11) can also be used in mixtures with dyestuffs, reductive bleaching agents, finishing agents, softeners, detergents and aftertreatment (rinsing) agents for laundry material. Furthermore, they can also be used for improving the aspect of soap.

The quantity of the compounds of formula (11) to be used according to the invention, calculated on the material to be optically brightened, may vary within wide limits. It can be easily determined and is generally between about 0.01% and about 1 The following Examples illustrate the invention, the parts and percentages being by weight unless stated otherwise. The ratio of parts by weight and parts by volume is that of the kilogram to the liter.

EXAMPLE 1 19.8 Parts of the vinylsulfonc compound (Table 1, general formula, U SO --CH=CH obtainaable according to the process described in German Offenlegungsschrift 2,011,552 were catalytically hydrogenated in dioxane with the addition of Raney-nickel. After the usual work-up, 12.4 parts of compound 101 (Table 1) were obtained. The product was recrystallized from n-butanol with the addition of active charcoal (m.p. 208 to 209C).

EXAMPLE 2 25.2 Parts of 3,3,4-trichloro-6-methylpropiophenone (m.p. 55 to 56C, obtained by Friedel- Crafts condensation of B-chloro-propionyl chloride with 3,4-dichloro-toluene according to Example 1 of German Offenlegungsschrift No. 2,011,552) were refluxed for 6 hours while stirring in 600 parts of water with the addition of 60 parts by volume of dimethylformamide with 20.7 parts of phenylhydrazine-4- sulfonic acid. The pH was then adjusted to 7 to 8 by means of a sodium carbonate solution and the product was precipitated while still hot, by the addition of 200 parts of sodium chloride. Stirring was continued, the product was suction-filtered and washed with a 10 sodium chloride solution and dried. After recrystallization from ethanol-containing water, 26.7 parts of compound 102 (Table 1) were obtained (decomposition at 270C).

EXAMPLE 3 13.0 Parts of compound 102 were suspended in 100 parts by volume of chlorobenzene. After the addition of 30 parts by volume of dimethylformamide and 10 EXAMPLE 4 1.5 Parts of compound 103 were dissolved at 60 to C in 20 parts by volume of pyridine. 10 Parts by volume of methanol were quickly added while stirring at 60C. The solution was immediately cooled and poured, while stirring, onto parts of ice. The product was suction-filtered, washed with water and methanol and dried. 1.2 Parts of compound 104 (Table 1) were obtained. The compound was recrystallized from chlorobenzene with the addition of active charcoal and bleaching earth (melting point 182 to 184C).

When a solution of stearylalcohol in pyridine was used instead of methanol and after adding, the whole was allowed to react for a short time at 100C., compound 105 (Table 1) was obtained according to the process described above. (melting point 109 to l 10C after recrystallization from chlorobenzene).

EXAMPLE 5 elevated temperature in dioxane with an excess of aqueous concentrated ammonia.

Compound 119 (Table 2) was obtained in a good yield according to the process described in Example 5 with the use of 3,3',4'-trichloro-6"ethyl propiophenone (see Example 12 of German Offenlegungsschrift No. 2,011,552).

EXAMPLE 6 20.2 Parts of compound 103 (Table 1 were suspended in 150 parts by volume of dioxane. After addition of a solution of 8.8 parts of morpholine in 20 parts by volume of dioxane, the whole was heated and stirred for 3 hours at 50C. Subsequently 200 parts by volume of water were added at this temperature, the whole was after-stirred, the substance was suction-filtered, washed with water and dried. 21.3 Parts of compound 107 (Table 1) were obtained. Compound 107 was recrystallized from chlorobenzene (melting point 223 to 224C).

EXAMPLE 7 12.1 Parts by compound 103 were refluxed for 3 hours in 200 parts by volume of dioxane with 6.1 parts of N,N-dimethyl-l,3-diamino-propane. Subsequently 250 parts of water were added, stirring was continued while cooling, the product was suction-filtered and washed several times with water. After drying, 12.4 parts of compound 108 (Table l) were obtained. The product was recrystallized from chlorobenzene with the addition of active charcoal and bleaching earth (melting point 162 to 163C).

EXAMPLE 8 5.0 Parts of compound 108 were dissolved at boiling temperature in 170 parts by volume of acetone. 2 Parts by volume of dimethylsulfate were dropped into the hot solution while stirring. The methosulfate precipitated immediately in crystalline form. Stirring was continued for 20 minutes, the precipitate was suction-filtered, washed several times with acetone and dried. 5.9 Parts of compound 109 (Table l) were obtained (melting point 207 to 209C).

EXAMPLE 9 25.2 Parts of 3,3,4-trichloro-6'-methylpropiophenone (see Example 2) were refluxed for 5 hours, while stirring, in 150 parts by volume of isopropanol and 50 parts of water with 20.7 parts of phenylhydrazine-4-carboxylic acid hydrochloride. After cooling, the product was suction-filtered, washed with isopropanol and water, and dried. 25.1 Parts of compound 110 (Table l) were obtained. The substance was purified by recrystallization from dimethylformamide with the addition of active charcoal and kieselguhr (decomposition at 326 to 329C).

Compound 120 (Table 2) was obtained in a good yield according to the process as described in Example 9 with the use of 3,3',4'-trichloro 6-ethylpropiophenone (see Example 12 of German Offenlegungsschrift No. 2,011,552).

EXAMPLE 17.5 Parts of compound 110 were introduced into 150 parts by volume of dioxane. After the addition of 10 parts by volume of thionyl chloride and 2 parts by volume of dimethylformamide, the whole was heated and stirred for 5 hours at to C. After cooling, the product was suction-filtered, washed with dioxane and dried. 17.0 Parts of compound 111 (Table l) were obtained (melting point 230 to 232C) with decomposition).

EXAMPLE 1 l 3.7 Parts of compound 111 were heated in 40 parts by volume of pyridine and 20 parts by volume of methanol, and the whole was stirred for 1 hour at to C. Subsequently stirring was continued, the precipitate was suction-filtered, washed with water and methanol and dried. 3.1 Parts of compound 1 12 (Table l were obtained. The product was recrystallized from chlorobenzene (melting point 205 to 206C). In an analogous manner with the use of ethanol, the ethyl ester 113 (Table l) was obtained.

EXAMPLE 12 3.7 Parts of compound 1 l 1 were stirred for 1 hour at 90 to 100C in 40 parts by volume of pyridine with 10 parts by volume of dimethylamino ethanol. After the addition of 160 parts by volume of water, the whole was allowed to cool, the product was suction-filtered, washed with water and dried. 3.3 Parts of compound 114 (Table l) were obtained. The substance was recrystallized from methanol with the addition of active charcoal (melting point 147 to 149C).

The methosulfate 115 (Table l) (melting point 225 to 228C) was obtained when compound 1 14, dissolved in acetone, was reacted with dimethylsulfate.

EXAMPLE 13 tallized from dimethylformamide (melting point 277 to 279C EXAMPLE 14 12.6 Parts of 3,3 ',4-trichloro-6'- methylpropiophenone (see Example 2) were refluxed for 6 hours in 250 parts by volume of isopropanol and 70 parts of water with the addition of hydrochloric acid with 9.3 parts of 4-cyanophenylhydrazine hydrochloride. After cooling, the product was suction-filtered, washed with isopropanol and water and dried. 10.2 Parts of compound 1 17 (Table l) were obtained (melting point 205 to 206C after recrystallization from nbutanol).

1n the same manner as described in Example 14 and with the use of the accordingly substituted phenylhydrazine hydrochlorides, there were obtained in good yields compounds 118 (Table l) and 124 127 (Table 4).

EXAMPLE 15 19.7 Parts of the sodium salt of the 3,4'-dichloro-6'- methylbenzalacetophenone-2-sulfonic acid (obtained from 3,4-dichloro-6-methyl-acetophenone and the sodium salt of benzaldehyde-Z-sulfonic acid, melting point 262 to 270C). were refluxed for hours in 300 parts of water with the addition of hydrochloric acid with 9.4 parts of phenylhydrazine-4-sulfonic acid. The solution was clarified, the pH was adjusted to 7 to 8 with sodium carbonate solution and mixed, while hot, with 35 parts of sodium chloride. Stirring was continued, the precipitate was suction-filtered, washed with a 5 sodium chloride solution and dried. The product was dissolved in water, allowed to crystallize, and separated after the addition of a small amount of sodium chloride. 21 .3 Parts of compound 121 (Table 3) were obtained (sodium chloride content 6 decomposition at about 360C) EXAMPLE 16 EXAMPLE 17 16.1 Parts of 3 ,4'-dichloro-6'-methyl-4- methoxybenzalacetophenone were refluxed for 14 hours in 400 parts by volume of isopropanol and 20 parts by volume of water with the addition of hydrochloric acid with 12.3 parts of phenylhydrazine-4- sulfonamide hydrochloride. After cooling, the product was suction-filtered, washed with isopropanol and water and dried. 18.0 Parts of compound 123 (Table 3) were obtained. After recrystallization from chlorobenzene with the addition of active charcoal and bleaching earth, the melting point was 221 to 223C.

EXAMPLE 18 A fabric made from polyamide 6 was treated at a goods-to-liquor ratio of l with a bath containing per liter 0.2% (calculated on the weight of the goods) of one of the compounds listed below and 10 ml/] of formic acid. The temperature of the bath was raised to 80C and the material therein was moved for 30 minutes. After rinsing and drying, the samples of the polyamide fabric showed excellent degrees of whiteness compared to the untreated material (DW raw: 73.1 according to Berger).

Compound No. DW

The degree of whiteness (DW) was determined by measuring it with the electric remission photometer ELREPHO (by Messrs. Zeiss, Oberkochen, Federal Republic of Germany) using the Xenon lamp and the filters F ML, and the degree of whiteness was calculated using the formula:

degree of whiteness (DW) Y 3 (Z X) (according to Berger, Die Farbe 8, 187 (1959)).

EXAMPLE 19 A knitted fabric made from cellulose 2 /2 acetate was treated, after the usual preliminary washing, at a goodsto-liquor ratio of l 20 for 45 minutes at C on a winch-back containing 0.3 (calculated on the weight of the goods) of one of the compounds listed below. Subsequently, the material was rinsed and dried as usual. Compared to the material which was only prewashed (DW: 76.0), the respective sample showed an excellent degree of whiteness.

Compound No. DW

EXAMPLE 20 Compound No. DW

EXAMPLE 21 A fabric made from cellulose 2 /2 acetate was impregnated with a bath containing 3 g/l of one of the optical brighteners listed below and 20 g/l of a mixture of adjuvants, consisting of parts of polyethylene glycol having an average molecular weight of 400 and 15 parts of an addition product of 5 moles of ethylene oxide and 1 mol of stearyl alcohol. The so-wetted textile material was squeezed in usual manner between rollers until it had a moisture content of 70 of its dry weight. Subsequently, it was exposed to a hot air treatment at C. Compared to the material which had only been prewashed, (DW: 76.0) the fabric samples thus treated showed the following degrees of whiteness:

EXAMPLE 22 A knitted fabric made from polyamide 6 was treated at a goods-to-liquor ratio of 1 20 with a bath containing 6 g/l of a washing agent of the following composit|on:

9.8 of isotridecanol-polyglycol ether having 8 mols of ethylene oxide per mol of isotridecanol i WI: Dr alcohol (C16 1g) 50 of sodium tripolyphosphate 6 of sodium metasilicate 4 of carboxymethyl cellulose (medium viscosity in a 2 solution according to Hoppler at 20C 1500 cP) 0.2 of one of the optical brighteners listed below Remainder: M1 80, and water The knitted fabric was washed for 10 minutes at 60C, rinsed and dried. This treatment was repeated up to 10 times. The knitted fabric samples showed very good degrees of whiteness compared to the material pre-washed without an addition of an optical brightener (DW: 80.1)

A fabric made from cellulose 2% acetate was treated at a goodsto-liquor ratio of l 20 with a bath containing 6 g/l of a detergent of the following composition:

9.8 of isotridecanol polyglycol ether (having 8 mols of ethylene oxide per mol of isotridecanol).

l of fatty alcohol (C 50 of sodium tripolyphosphate Compound No. Washed once Washed 10 times DW DW EXAMPLE 24 A commercial copolymer containing more than 85 of polyacrylonitrile was dissolved in dimethyl form- 5 amide, and 0.02 of compound 106 (Table 1), calculated on the copolymer, was added to this solution. This polymer solution was spun in usual manner, the solvent having been vaporized by means of hot air. The ma ment cable coagulated, was treated in usual manner, curled and dried and had an excellent degree of whiteness compared to the material produced under the same conditions but without the addition of the optical brightener.

Similarly good values were obtained when the compound 1 19 (Table 2) was used.

2OE3-20Q 270 decomp..

161M105 decomp.

Table 3-Continued Nr. W U mpC our --l23A ?7 S c1 CH H O NH SO H SO H I 3 qiiile 4' CH i i. Cl \IJ l H A N-'\ I \\-U2 CH 011., c1

Hr. U IL, U Fp c 124 H H C1 12) 150 125 ll ()1 C1 16'] 168 1?? CF 11 L1";S 196 l5! l i alkylene lower alkyl morpholinium-lower alkyl- A compound of the formula wherein:

R is lower alkyl; V is hydrogen, lower alkyl, hydroxy-lower alkyl,

halo-lower alkyl, phenyl, halophenyl, lower alkylphenyl, lower alkoxy-phenyl or sulfophenyl; and U is -SO N Y, Y wherein Y, and Y each is hydrogen, lower alkyl, di(lower alkyl)-aminolower alkylene, tri(lower alkyl)-ammonium-lower alkylene, morpholino-lower alkylene, piperidino-lower ene, or lower alkyl-piperidinium-lower alkylene. 2. A compound according to claim 1, wherein U is sulfonamide, sulfonic acid morpholide, sulfonic acid 3-(dimethylamino)-propyl amide or sulfonic acid B-(trimethylammonium)-propyl amide methosulfate.

3. A compound according to claim 1 wherein R is I 7. -A compound according to claim 1 wherein U is' sulfonam ide.

8. A compound according to claim 1 wherein U is sulfonic acid-( 3-trimethylammonium propylamidemethosulfate. 

1. A COMPOUND OF THE FORMULA
 2. A compound according to claim 1, wherein U is sulfonamide, sulfonic acid morpholide, sulfonic acid 3-(dimethylamino)-propyl amide or sulfonic acid 3-(trimethylammonium)-propyl amide methosulfate.
 3. A compound according to claim 1 wherein R is methyl and V is hydrogen.
 4. The compound according to claim 3, wherein U is sulfonamide.
 5. The compound according to claim 3, wherein U is sulfonic acid-(3-trimethylammonium)-propylamide methosulfate.
 6. A compound according to claim 1 wherein: R is methyl or ethyl.
 7. A compound according to claim 1 wherein U is sulfonamide.
 8. A compound according to claim 1 wherein U is sulfonic acid-(3-trimethylammonium)-propylamiDemethosulfate. 